January 22, 2010
TRANS GENIC INC.
News Release

Launch of Anti Human GPCR Monoclonal Antibodies
 
We hereby announce that TRANS GENIC INC. has released anti human GPCR monoclonal antibodies developed by GANP® Mouse Technology (our unique technology for producing high-affinity antibodies) as research reagents on January 22, 2010.
Details of the products are as follows.  
Product Name Quantity Application Price (Tax included) Code
Anti Human HTR5A Monoclonal Antibody (Clone No. 2D3) 50 μg ELISA,IHC 57,750 yen KX574
Anti Human SSTR2 Monoclonal Antibody （Clone No. 1B7） 50 μg ELISA,IHC 57,750 yen KX575

Anti Human RXFP3 Monoclonal Antibody
（Clone No. 2H10）

50 μg

ELISA,IHC

57,750 yen

KX576

Anti Human ADORA3 Monoclonal Antibody
（Clone No. 1C9）

50 μg

ELISA,IHC

57,750 yen

KX577

◆Release Date:

January 22, 2010
◆Distribution Method:

Sold through our distributors (Cosmo Bio Co., Ltd., Funakoshi Corporation,    Wako     Pure Chemical Industries, Ltd. and SCETI K.K.)

◆Product Information: Please click the codes on the list and refer to the product data sheets
◆Reference:

HTR5A（5-hydroxytryptamine (serotonin) receptor 5A   （5-HT5A、MGC138226、 HTR5A）
//Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.
//Subcellular location: Cell membrane; Multi-pass membrane protein.
//Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

SSTR2（somatostatin receptor 2）
//Function: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels.
//Subcellular location: Cell membrane; Multi-pass membrane protein.
//Tissue specificity: Cerebrum and kidney. In lesser amounts in jejunum, colon and liver.
//Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

RXFP3（relaxin receptor 3）  （SALPR、RLN3R1、RXFPR3、 GPCR135、MGC141998、MGC142000、RXFP3）
//Function: Receptor for relaxin-3. Binding of the ligand inhibit cAMP accumulation.
//Subcellular location: Cell membrane; Multi-pass membrane protein.
//Tissue specificity: Expressedpredominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis.
//Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

ADORA3（adenosine A3 receptor）  （A3AR、AD026、 bA552M11.5、 RP11-552M11.7、 ADORA3）
//Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction.
//Subcellular location: Cell membrane; Multi-pass membrane protein.
//Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
   
For inquiries and information:
Investors Relations of TRANS GENIC INC. Tel. 078-306-0295
 
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