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Contract service for non-clinical study

TRANS GENIC offers drug efficiency and pharmacological test, safety pharmacological study, and disposition study using small or large animals at Kobe laboratory and JOINN laboratory in China. TRANS GENIC proposes proper test plan in response to request from customers, and provides high-quality study based on its extensive experience.

Drug efficiency and pharmacological study

TRANS GENIC produces a wide variety of disease-model animals using small animals such as mice, or large animals such as monkeys and pigs, and carries out drug efficiency and pharmacological study for medicines. Drug efficiency and pharmacological study using genetically altered mice is also available.
TRANS GENIC provides consulting service on test system construction based on its extensive experience. Please feel free to contact us.

Central nervous system

Type of study and method Corresponding Animals
Learning・memory MPTP-induced Parkinson's disease model Monkey
Stroke Middle cerebral artery occlusion(awake ligation)model-acute, chronic, ischemia-reperfusion-

Rat, Monkey
Analgesia Neuropathic pain model(sciatic nerve ligation)

Rat, Monkey
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Metabolic/Endocrine system

Type of study and method Corresponding Animals
Obesity・diabetes Hypothalamic obesity(metabolic syndrome)model Monkey
Streptozocin (STZ)-induced type-1 diabetes model Rat, Monkey
Hyperlipidemia Hyperlipidaemia model caused by hypercholesterolemic diet Monkey
Arteriosclerosis In-stent restenosis model caused by hypercholesterolemic diet Monkey
Coronary sclerosis model caused by hypercholesterolemic diet Monkey
Vascular endothelium injury arteriosclerosis model Monkey
Hepatic injury Carbon tetrachloride-induced hepatic impairment model Rat, Monkey
Galactosamine-induced hepatic impairment model Rat, Monkey
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Inflammation/Immunity

Type of study and method Corresponding Animals
Arthritis Adjuvant arthritis model Rat
Type-2 collagen arthritis model
Rat, Monkey
Decreased immunity Cold Stress-Induced decreased immunity model Mouse, Rat
Anticancer drug-induced decreased immunity model Mouse, Rat
Reticuloendotherial system Measurement of reticuloendothelial phagocytic activity Rat
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Renal/Urinary system

Type of study and method Corresponding Animals
Renal disorder Renal Failure Remnant Kidney Model (5/6 Nephrectomy)
Rat, Monkey
Streptozocin-induced diabetic nephropathy model Rat, Monkey
Bladder function Cystometry ( measurement of intravesical pressure) Monkey
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Cardiovascular system

Type of study and method Corresponding Animals
Ischemic heart disease Myocardial infarction model Rat
Monkey
Pig
Ischemia-reperfusion model
Chronic myocardial infarction model Monkey, Pig
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Digestive system

Type of study and method Corresponding Animals
Peptic ulcer Various stress-induced gastro and small-intestinal mucosal injury model Rat
Others Growth suppression model (5/6 Nephrectomy) Rat
Small bowel resection-induced nutrition disorder model Rat
Gastrointestinal motility measurement Monkey
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Malignant tumor(tumor bearing)

Type of study and method Corresponding Animals
Cancer cell implant model Drug-resistance cancer cell implant model Nude Mouse
ACHN cell (human renal cancer)
OS-RC-2 cell (human renal cancer)
A-375 cell (human malignant melanoma)
KB cell (human nasal and throat cancer)
HeLaS3 cell (human uterine cervical cancer)
HCT-15 cel
T.T cell
Yoshida sarcoma Rat
AH130 cell
P388 cell Mouse
Sarcoma180 cell
B-16F0 cell
Leukemia ENU-induced Leukemia model Rat
Others In vitro test utilizing various cancer cells -

* Please feel free to contact us concerning subcutaneous implantation, intraperitoneal implantation, liver transplantation, subrenal capsule assay. Lung metastatic model is also available.

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Bone-related

Type of study and method Corresponding Animals
Osteoporosis Hepatopathic osteoporosis model (carbon tetrachloride-induced hepatic disorder) Rat
Nephropathic osteoporosis model (STZ-induced diabetic nephropathy)
Oophorectomy-induced osteopenia
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Dermatology-related

Type of study and method Corresponding Animals
Wound Incised wound healing model Rat
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Ophthalmology-related

Type of study and method Corresponding Animals
Intraocular pressure measurement Contact-type intraocular pressure measurement (unanesthetized) Monkey
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Others

試験 Corresponding Animals
Central venous catheter placement (infusion) model [unrestrained] Rat, Monkey
Various specimens for biochemistry and pharmacological experiment Monkey
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Consulting service

TRANS GENIC provides consulting service on various drug efficiency and pharmacological studies. Please feel free to contact us.

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